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Cancer Cell International

Subject Areas: Cancer Research
Publisher: BioMed Central - Springer Journals
SJR: 62

Open Access

Journal Article

Correction to: Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

Xu, Peng; Hu, Kang; Zhang, Ping; Sun, Zhi-Gang; Zhang, Nan

2023 Cancer Cell International

doi:10.1186/s12935-023-03030-5 pmid:37633895
Open Access

Journal Article

Long non-coding RNA signature in colorectal cancer: research progression and clinical application

Wu, Yudi; Xu, Xiangshang

2023 Cancer Cell International

doi:10.1186/s12935-023-02867-0 pmid:36797749

Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene...
Open Access

Journal Article

Changes in HER3 expression profiles between primary and recurrent gynecological cancers

Kojima, Yuki; Sudo, Kazuki; Yoshida, Hiroshi; Yazaki, Shu; Tokura, Momoko; Mizoguchi, Chiharu; Okuma, Hitomi S.; Kita, Shosuke; Yamamoto, Kasumi; Nishikawa, Tadaaki; Noguchi, Emi; Shimoi, Tatsunori; Tanase, Yasuhito; Uno, Masaya; Ishikawa, Mitsuya; Kato, Tomoyasu; Koyama, Kumiko; Kobayashi, Maki; Kakegawa, Tomoya; Fujiwara, Yasuhiro; Yonemori, Kan

2023 Cancer Cell International

doi:10.1186/s12935-022-02844-z pmid:36737733

BackgroundHuman epidermal growth factor receptor-3 (HER3) is a member of the epidermal growth factor receptor family of receptor tyrosine kinases, and its overexpression is associated with inferior prognosis in several cancers. However, it is unclear whether HER3 expression status changes in...
Open Access

Journal Article

Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma

Chang, Pei-Chi; Lin, Yu-Chieh; Yen, Hui-Ju; Hueng, Dueng-Yuan; Huang, Shih-Ming; Li, Yao-Feng

2023 Cancer Cell International

doi:10.1186/s12935-023-02912-y pmid:37029364

IntroductionGlioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and chemotherapy, Temozolomide (TMZ). However, tumors tend to develop TMZ resistance which leads to therapeutic failure. Ancient ubiquitous protein 1...
Open Access

Journal Article

Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway

Zhong, Ying; Li, Fangyuan; Zhang, Sumei; Yang, Zhenli; Ren, Xinyu; Cao, Xi; Xu, Yali; Guo, Dan; Zhou, Yidong; Mao, Feng; Shen, Songjie; Sun, Qiang

2023 Cancer Cell International

doi:10.1186/s12935-023-02917-7 pmid:37069585

BackgroundImmune checkpoint inhibitors are the most studied forms of immunotherapy for triple-negative breast cancer (TNBC). The Cancer Genome Map (TCGA) and METABRIC project provide large-scale cancer samples that can be used for comprehensive and reliable immunity-related gene...
Open Access

Journal Article

Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma

Li, Jian; Yin, Jingyang; Li, Wenhua; Wang, Huaizhi; Ni, Bing

2023 Cancer Cell International

doi:10.1186/s12935-022-02836-z pmid:36647100

BackgroundMultiple molecular subtypes with distinct clinical outcomes in pancreatic adenocarcinoma (PAAD) have been identified in recent years. Cuproptosis is a new form of cell death that likely involved in tumor progression. However, the cuproptosis-related molecular subtypes as well as its...
Open Access

Journal Article

Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis

An, Lijun; Gong, Huiyuan; Yu, Xiaojing; Zhang, Wangming; Liu, Xiaohua; Yang, Xiaomin; Shu, Liping; Liu, Jielin; Yang, Liuqi

2023 Cancer Cell International

doi:10.1186/s12935-023-02993-9 pmid:37480012

PurposeMyelin and lymphocyte protein 2 (MAL2) is mainly involved in endocytosis under physiological conditions and mediates the transport of materials across the membranes of cell and organelle. It has been reported that MAL2 is significantly upregulated in diverse cancers. This study aimed to...
Open Access

Journal Article

RGS proteins and their roles in cancer: friend or foe?

Li, Lin; Xu, Qiang; Tang, Chao

2023 Cancer Cell International

doi:10.1186/s12935-023-02932-8 pmid:37118788

As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G protein signaling (RGS) proteins facilitate various downstream cellular signalings through regulating kinds of heterotrimeric G proteins by stimulating the guanosine triphosphatase (GTPase) activity of...
Open Access

Journal Article

The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target

Sameti, Pouriya; Tohidast, Maryam; Amini, Mohammad; Bahojb Mahdavi, Seyedeh Zahra; Najafi, Souzan; Mokhtarzadeh, Ahad

2023 Cancer Cell International

doi:10.1186/s12935-023-02972-0 pmid:37438760

A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers. Therefore, they are expected to play important roles in tumorigenesis by functioning as oncogenic (oncomiRs) or...
Open Access

Journal Article

Implications of CRNDE in prognosis, tumor immunity, and therapeutic sensitivity in low grade glioma patients

Yang, Chen; Jiang, Yingchuan; Hu, Fan; Li, Qiuping; Qi, Biao

2023 Cancer Cell International

doi:10.1186/s12935-023-02930-w pmid:37194105

BackgroundColorectal tumor differentially expressed (CRNDE) is specifically expressed in human brains and is the most highly expressed lncRNA in gliomas. Nevertheless, its implications in low grade glioma (LGG) are still indistinct. This study presented systematic analyses of CRNDE in LGG...

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