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Journal of Receptors and Signal Transduction

Subject Areas: Biochemistry
Publisher: Taylor & Francis - Taylor & Francis
ISSN: 1079-9893
SJR: 48

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Journal Article

cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies

Khorasani, Milad; Alaei, Maryam

2024 Journal of Receptors and Signal Transduction

doi:10.1080/10799893.2024.2325353 pmid:38470108

Abstract Breast cancer is a complex malignancy with diverse molecular and cellular subtypes and clinical outcomes. Despite advances in treatment, breast cancer remains a significant health challenge. However, recent advances in cancer immunotherapy have shown promising results in the treatment...
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Journal Article

Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development

Chauhan, Arushi; Singh, Jitender; Sangwan, Namrata; Avti, Pramod K.

2024 Journal of Receptors and Signal Transduction

doi:10.1080/10799893.2024.2332886 pmid:38529713

Abstract Purpose The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at the receptor’s allosteric region is being increasingly studied for...

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