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The Warburg effect or aerobic glycolysis is a hallmark of cancer. Lactate
dehydrogenase (LDH), which catalyzes conversion of pyruvate into lactate, serves
a critical role during Warburg effect. LDH A chain (LDHA), a member of the LDH
family, is upregulated in...
Pharmacological reactivation of tumor‑suppressor protein p53 has acted as
a promising strategy for more than 50% of human cancers that carry a non‑functional
mutant p53 (mutp53). p53 plays a critical role in preserving
genomic integrity and DNA...
Tumor‑associated macrophage (TAMs) are paramount for tumor progression and
immune tolerance in the tumor microenvironment of various types of cancer, including
liver cancer. The aim of the present study was to investigate the effect of vascular
We previously reported that both cannabidiol (CBD) and low‑dose naltrexone
(LDN) exhibit complex effects on G‑protein coupled receptors, which can impact
the expression and function of other members of this superfamily. These receptors
feed into and interact...
Circular RNAs (circRNAs) are a type of non‑coding RNA with important roles
in the regulation of various biological processes involved in malignant progression.
However, the potential molecular mechanisms and roles of circRNAs in kidney cancer
have remained to...
Cellular inhibitor of apoptosis protein‑1 (cIAP1) is a key regulator of
programmed cell death and is known to be associated with chemotherapeutic resistance.
The present study aimed to investigate the antitumor efficacy of birinapant, a
Cepharanthine, a biscoclaurine alkaloid isolated from the roots of Stephania cephalantha
Hayata, has been reported to demonstrate antitumor activity across multiple cancer
types; however, the mechanisms are still under investigation. High transcriptional...
Pancreatic cancer (PC) is one of the most lethal diseases, with a 5‑year
survival rate of <9%. Perineural invasion (PNI) is a common pathological
hallmark of PC and is correlated with a poor prognosis in this disease. Hyperglycemia
has been shown to promote...
Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer,
but resistance is common. The initial response to platinum‑based chemotherapy
is as high as 80%, but in most advanced patients, final relapse and death are
caused by acquired drug...
Following the publication of this paper, it was drawn to the Editors' attention
by a concerned reader that certain of the western blotting data shown in Fig. 5D
were strikingly similar to data appearing in different form in other articles
by different authors....
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