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Cancer has recently been identified as the leading cause of mortality worldwide.
Several conventional treatments and cytotoxic immunotherapies have been developed
and made available to the market. Considering the complex behavior of tumors and
Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial,
herbaceous member of the Asteraceae family. Besides its use in modern Chinese
herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece,
Egypt and China. It is...
B-cell receptor (BCR) signaling is important for the development and maturation
of normal B-cells and plays a key role in B-cell malignancies. Bruton's tyrosine
kinase (BTK), a crucial terminal kinase enzyme in BCR signaling, has emerged as
an attractive target...
Colorectal cancer (CRC) is one of the four leading causes of cancer‑related
mortality worldwide. Even though over the past few decades the global scientific
community has made tremendous efforts to understand this entity, many questions
remain to be raised on...
Platinum‑containing doublet chemotherapy is the cornerstone of lung cancer
treatment; however, cisplatin resistance is a major obstacle in the treatment
of lung cancer. However, the mechanism underlying this resistance has not been
fully elucidated. Previous...
Single nucleotide polymorphisms (SNPs) are the most common genetic variation
in mammalian cells with prognostic potential. Anillin‑actin binding protein (ANLN)
has been identified as being involved in PI3K/PTEN signaling, which is critical
in cell life/death...
Toll‑like receptor 2 (TLR2), is an important pattern recognition receptor
which serves a role in chronic inflammation of the liver. However, the role of
TLR2 in the progression of human hepatocellular carcinoma (HCC) remains unknown.
The aim of the present...
The minichromosome maintenance (MCM) gene family plays an essential role
in DNA replication and cell cycle progression. However, MCM gene expression has
not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the
expression, prognostic value...
Ribosomes are important cellular components that maintain cellular homeostasis
through overall protein synthesis. The nucleolus is a prominent subnuclear structure
that contains ribosomal DNA (rDNA) encoding ribosomal RNA (rRNA), an essential
Endometrial polyps are common, yet the molecular mechanisms underlying their
formation and progression remain unclear. We examined gene mutations possibly
related to the pathogenesis of endometrial polyps, as well as to their clinical
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