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New clinical strategies and innovative approaches to the use of mitoxantrone include high‐dose treatment, new combinations such as 5‐fluorouracil with leucovorin (NFL), and neoadjuvant therapy for metastatic and primary breast cancer. Its use in other malignancies such as acute leukaemia and...
The combination of mitoxantrone (12 mg/m2 i.v., day 1) 5‐fluorouracil (350 mg/m2 i.v. days 1–3) and leucovorin (300 mg i.v. days 1–3) is an active and well‐tolerated regimen for metastatic breast cancer. We compared this regimen to a standard CMF regimen (cyclophosphamide 600 mg/m2 i.v. day 1;...
The development of more effective treatment strategies currently provides the only realistic hope of reducing breast cancer mortality. Among such treatments, the use of high‐dose chemotherapy (HDC) has been proposed as a potentially curative strategy. Consideration of the factors involved in the...
The use of neoadjuvant chemotherapy in primary breast cancer is based on sound theoretical, experimental and clinical principles. Higher objective response rates have been seen in patients with locally advanced breast carcinoma. Furthermore, when used in patients with operable breast carcinomas,...
Low‐grade lymphoma is the commonest form of lymphoma in the USA and Europe with a long natural history with multiple responses and relapses. The tendency has been to use simple oral medication until patients have more advanced aggressive disease but new agents such as the purine analogues,...
Based on promising preclinical data, a progressive series of evaluations of the use of high‐dose mitoxantrone‐based chemotherapy was initiated in acute leukaemia patients. A preliminary phase I study demonstrated that up to 80 mg/m2 of mitoxantrone in combination with cytarabine 3 g/m2 daily for...
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