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Thrombomodulin is important for the production of activated protein C (APC), a molecule with significant regulatory roles in coagulation and inflammation. To address known molecular incompatibilities between pig thrombomodulin and human thrombin that affect the conversion of protein C into APC,...
There have been high expectations in recent years of using xenotransplantation and regenerative medicine to treat humans, and pigs have been utilized as the donor model. Pigs used for these clinical applications must be microbiologically safe, that is, free of infectious pathogens, to prevent...
Replacement of insulin‐producing pancreatic beta‐cells by islet transplantation offers a functional cure for type‐1 diabetes (T1D). We recently demonstrated that a clinical grade alginate micro‐encapsulant incorporating the immune‐repellent chemokine and pro‐survival factor CXCL12 could protect...
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