The FASEB Journal

Journal Article

Neutrophil extracellular traps facilitate sympathetic hyperactivity by polarizing microglia toward M1 phenotype after traumatic brain injury

Qu, Xiaolin; Hou, Xiaoxiang; Zhu, Kaixin; Chen, Wen; Chen, Kun;

2023 The FASEB Journal

doi:10.1096/fj.202300752r pmid:37534961

Traumatic brain injury (TBI), particularly diffuse axonal injury (DAI), often results in sympathetic hyperactivity, which can exacerbate the prognosis of TBI patients. A key component of this process is the role of neutrophils in causing neuroinflammation after TBI by forming neutrophil...

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Journal Article

Kinetics of skeletal muscle regeneration after mild and severe muscle damage induced by electrically‐evoked lengthening contractions

Bernard, Clara; Jomard, Charline; Chazaud, Bénédicte; Gondin, Julien

2023 The FASEB Journal

doi:10.1096/fj.202201708rr pmid:37534948

Post‐injury skeletal muscle regeneration requires interactions between myogenic and non‐myogenic cells. Our knowledge on the regeneration process is mainly based on models using toxic, chemical, or physical (e.g., based on either muscle freezing or crushing) injury. Strikingly, the time course...

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Journal Article

The role of zinc finger proteins in malignant tumors

Zhao, Jia; Wen, Doudou; Zhang, Shubing; Jiang, Hao; Di, Xiaotang

2023 The FASEB Journal

doi:10.1096/fj.202300801r pmid:37615242

Zinc finger proteins (ZNFs) are the largest family of transcriptional factors in mammalian cells. Recently, their role in the development, progression, and metastasis of malignant tumors via regulating gene transcription and translation processes has become evident. Besides, their possible...

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Journal Article

PCSK9 causes inflammation and cGAS/STING pathway activation in diabetic nephropathy

Feng, Zhicai; Liao, Xiangyu; Peng, Juan; Quan, Jingjing; Zhang, Hao;

2023 The FASEB Journal

doi:10.1096/fj.202300342rrr pmid:37561547

Our previous research revealed that an increase in PCSK9 is linked to aggravated inflammation in the kidneys of mice affected by a high‐fat diet and streptozotocin (HFD/STZ) or in HGPA‐induced HK‐2 cells. Furthermore, the cGAS/STING pathway has been reported to be involved in diabetic nephropathy...

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Journal Article

Deoxyribonucleoside treatment rescues EtBr‐induced mtDNA depletion in iPSC‐derived neural stem cells with POLG mutations

Kristiansen, Cecilie Katrin; Furriol, Jessica; Chen, Anbin; Sullivan, Gareth John; Bindoff, Laurence A.;

2023 The FASEB Journal

doi:10.1096/fj.202300650rr pmid:37584631

Mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol‐γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause of mitochondrial disease, treatments for POLG‐related disorders remain elusive. In...

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Journal Article

Erratum to “DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor‐β endocytosis through Caveolin‐1 in vascular smooth muscle cells”

2023 The FASEB Journal

doi:10.1096/fj.202301586 pmid:37594909

LitStream

Journal Article

Erratum to “Aortic carboxypeptidase‐like protein, a putative myokine, stimulates the differentiation and survival of bone‐forming osteoblasts”

2023 The FASEB Journal

doi:10.1096/fj.202301659 pmid:37638527

LitStream

Journal Article

Exosomal circBBS2 inhibits ferroptosis by targeting miR‐494 to activate SLC7A11 signaling in ischemic stroke

Hong, Ting; Zhao, Tingting; He, Wei; Xia, Jian; Huang, Qing;

2023 The FASEB Journal

doi:10.1096/fj.202300317rrr pmid:37603538

Umbilical cord‐mesenchymal stem cells (UC‐MSCs)‐derived exosomes have been considered as an effective treatment for ischemic stroke. CircRNA BBS2 (circBBS2) was demonstrated to be down‐regulated in patients with ischemic stroke. However, the role of UC‐MSCs‐derived exosomal circBBS2 in ischemic...

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Journal Article

Inhibition of CK2α accelerates skin wound healing by promoting endothelial cell proliferation through the Hedgehog signaling pathway

Zhu, Junjie; Chen, Peng; Liang, Jiaojiao; Wu, Zhaohang; Jin, Haiqun;

2023 The FASEB Journal

doi:10.1096/fj.202300478rr pmid:37594910

Diabetes is a chronic disease characterized by perturbed glucose and lipid metabolism, resulting in high blood glucose levels. Many complications induced by endothelial dysfunction can cause disability and even death of diabetic patients. Here, we found that the protein level of casein kinase 2α...

LitStream

Journal Article

Nuclear protein‐1 is the common link for pathways activated by aging and obesity in chondrocytes: A potential therapeutic target for osteoarthritis

Tan, Li; Armstrong, Alexandra R.; Rosas, Samuel; Patel, Chirayu M.; Vander Wiele, Sabrina S.;

2023 The FASEB Journal

doi:10.1096/fj.202201700rr pmid:37566478

Pathways leading to osteoarthritis (OA) are diverse depending on the risk factors involved; thus, developing OA therapeutics has been challenging. Here we report that nuclear protein‐1 (Nupr1), a stress‐inducible protein/transcription factor, is activated by pathways associated with obesity and...

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