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Scientia Pharmaceutica

Subject Areas: Pharmaceutical Science
Publisher: Multidisciplinary Digital Publishing Institute - Multidisciplinary Digital Publishing Institute
ISSN: 2218-0532
SJR: 46

Open Access

Journal Article

Diastereomers of Spheroidal Form and Commercially Available Taxifolin Samples

Terekhov, Roman P.; Melnikov, Evgeny S.; Nikitin, Ilya D.; Tokareva, Margarita A.; Rodina, Tatyana A.; Savina, Anastasiya D.; Pankov, Denis I.; Zhevlakova, Anastasiya K.; Beloborodov, Vladimir L.; Selivanova, Irina A.

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010005

Taxifolin is a natural polyphenol belonging to the class of flavonoids. The structure of this compound is characterized by the presence of two chiral centers. The spheroidal form of taxifolin (TAXs) has emerged as a promising modification due to enhanced solubility, higher safety profile, and...
Open Access

Journal Article

The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties

Ferdosh, Sahena

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010006

Calophyllum inophyllum L. has been used for many generations by Pacific Islanders because of its numerous health and aesthetic advantages. The leaves, stems, roots, fruits, flowers, and seeds of this plant contain significant phytochemicals, including flavonoids, coumarins, fatty acids, and...
Open Access

Journal Article

The Risks of “Getting High” on Over-the-Counter Drugs during Pregnancy

Ősz, Bianca-Eugenia; Ștefănescu, Ruxandra; Sălcudean, Andreea; Jîtcă, George; Vari, Camil-Eugen

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010007

Easy access to over-the-counter (OTC) drugs makes it possible to procure active substances that normally used in therapeutic doses do not raise health problems. The use of high doses of OTC drugs containing codeine, loperamide, pseudoephedrine, diphenhydramine or dimenhydrinate, as well as the...
Open Access

Journal Article

A Thermal-Analysis-Technique-Based Mechanistic Approach toward the Release of Omeprazole from Solid Dosage Forms

Agapakis, Georgios; Siamidi, Angeliki; Kikionis, Stefanos; Vlachou, Marilena; Pippa, Natassa

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010008

The design, development, and release kinetics of omeprazole (OME) from solid dosage forms have been investigated. These formulations were examined for their resilience in pH = 4.5 buffer solutions and their rate of disintegration in a small-intestine-like environment (pH = 6.8). The results were...
Open Access

Journal Article

Effect of Zoapatle (Montanoa tomentosa) on Inflammatory Markers in a Murine Model of Ventricular Hypertrophy

López-Luna, Carlos Enrique; Vargas-De-León, Cruz; Gutiérrez-Rojas, Rocio Alejandra; Aguayo-Cerón, Karla Aidee; Calzada-Mendoza, Claudia Camelia; Huang, Fengyang; Romero-Nava, Rodrigo; Ocharan-Hernandez, Maria Esther

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010009

Zoapatle, a native plant utilized for centuries in traditional Mexican medicine, is abundantly found in Mesoamerica and northern South America. Pleiotropic effects of this genus have been recognized, primarily inducing alterations in smooth muscle contractility in animal models. The aim of this...
Open Access

Journal Article

Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the Composition

Bartoníková, Kamila; Špaglová, Miroslava; Papadakos, Martina; Hanko, Michal; Macho, Oliver

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010010

(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets containing metronidazole (167 mg/g). (2) Methods: The...
Open Access

Journal Article

The Potential of Incorporating a Pharmacist-Only Medicine Category in Poland

Zaprutko, Tomasz; Sprawka, Józefina; Maciuszek-Bartkowska, Barbara; Ratajczak, Piotr; Kopciuch, Dorota; Paczkowska, Anna; Kus, Krzysztof

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010011

Pharmacists play an important role, being increasingly focused on patient care and pharmaceutical services. This trend is also noticeable in Poland. Thus, we aimed to study the opinions of Polish pharmacists to determine the potential for introducing a new category of pharmacist-only medicines...
Open Access

Journal Article

Attenuation of Pulmonary Damage Associated with COPD in a Cadmium-Exposed Model Due to the Administration of a siRNA Targeting PAD4

Ocampo-Ortega, Sergio Adrian; Cabrera-Becerra, Sandra Edith; Sierra-Sanchez, Vivany Maydel; García-Rubio, Vanessa Giselle; Blancas-Napoles, Citlali Margarita; Romero-Nava, Rodrigo; Huang, Fengyang; Hong, Enrique; Aguilera-Méndez, Asdrúbal; Villafaña, Santiago

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010012

Chronic obstructive pulmonary disease (COPD), characterised by persistent airflow limitation during breathing, is considered to be the third leading cause of death worldwide. Among the mechanisms involved in this pathology is the excessive generation of neutrophil extracellular traps (NETs),...
Open Access

Journal Article

Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia

Baek, Eun Bok; Hong, Eun-Ju; Kim, Jung-Hee; Kim, Min; Ahn, Jongmin; Kwun, Hyo-Jung

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010013

Benign prostatic hyperplasia (BPH) is a common disease in aging men. Panicum dichotomiflorum (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous...
Open Access

Journal Article

New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes

Gordeeva, Daria S.; Sitenkova (Bukhovets), Aleksandra V.; Moustafine, Rouslan I.

2024 Scientia Pharmaceutica

doi:10.3390/scipharm92010014

The aim of this study was the analysis of interpolyelectrolyte complexes (IPECs) based on Eudragit® EPO and Eudragit® L100 as prospective carriers for gastroretentive drug delivery systems (GRDDS) using two model drugs: metronidazole (MZ) and acyclovir (ACR). Eudragit® EPO/L100 IPECs with...

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