Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue.

Human Heredity

Subject Areas: Genetics
Publisher: S. Karger AG - Karger
ISSN: 0001-5652
SJR: 64

LitStream

Journal Article

Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes

Yu, Ying; Chen, Siyuan; Jones, Samantha Jean; Hoque, Rawnak; Vishnyakova, Olga; Brooks-Wilson, Angela; McNeney, Brad

2022 Human Heredity

doi:10.1159/000525650 pmid:35767963

Introduction: Increasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommodate data sparsity, which arises from unbalanced case-control ratios and/or rare genetic variants. Sparseness leads to maximum likelihood estimators (MLEs) of log-OR...
LitStream

Journal Article

Mutational Screening for Mitochondrial tRNA Genes in 100 Women with Pre-Eclampsia

Zhou, Baohua; Chu, Xuelian; Zhang, Caijuan; Liang, Xiufeng

2022 Human Heredity

doi:10.1159/000525663 pmid:35850107

Introduction: Impairment of mitochondrial function caused by pathogenic mitochondrial DNA (mtDNA) mutations has been found to be associated with pre-eclampsia (PE). However, the underlying mechanism of PE remains poorly undetermined. The aim of this study is to evaluate the relationship between...
LitStream

Journal Article

Common Variants in Neuraminidase Genes Contribute to Predisposition to and Progression of Chronic Heart Failure

Li, Shiyang; Wang, Yuehong; Zeng, Xiaobing; Zhang, Yanyu; Wang, Shihai; Liu, Yuyong; Xu, Dawen; Lan, Jianjun; Hu, Dong

2022 Human Heredity

doi:10.1159/000525713 pmid:35764075

Introduction: The role of neuraminidases in cardiovascular disease has recently gained increasing attention. However, the association between neuraminidase gene polymorphisms and heart failure (HF) has not yet been investigated. Methods and Results: Genotyping of nine single-nucleotide...
LitStream

Journal Article

The Prevalence of JAK2 Exon 12 Mutations in Vietnamese Patients with JAK2 V617F-Negative Polycythemia Vera: Frequent or Rare?

Ngoc, Nguyen Thy; Linh, Nguyen Thuy; Xuan, Nguyen Thi

2022 Human Heredity

doi:10.1159/000526201 pmid:35921805

Purpose: Polycythemia vera is a hematological malignancy characterized by the overproduction of red blood cells in the bone marrow. Pathogenesis of polycythemia vera was thought to be caused by genetic mutations of the Janus kinase 2 (JAK2) gene, especially the JAK2 V617F and exon 12 mutations,...

results per page

Prev
1
Next